Recent advances in ionic current rectification based nanopore sensing: a mini-review

Shujie Zhang; Wei Chen; Laibo Song; Xiaohong Wang; Weilun Sun; Pengyun Song; Ghazala Ashraf; Bo Liu; Yuan-Di Zhao

Sensors and Actuators Reports (Nov 2021)

Recent advances in ionic current rectification based nanopore sensing: a mini-review

Shujie Zhang,
Wei Chen,
Laibo Song,
Xiaohong Wang,
Weilun Sun,
Pengyun Song,
Ghazala Ashraf,
Bo Liu,
Yuan-Di Zhao

Affiliations

Shujie Zhang: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Wei Chen: Corresponding author.; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Laibo Song: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Xiaohong Wang: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Weilun Sun: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Pengyun Song: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Ghazala Ashraf: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Bo Liu: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Yuan-Di Zhao: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

Journal volume & issue: Vol. 3
p. 100042

Abstract

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In recent years, the intensive studies have been devoted to nanopores due to their unique charge transport properties including ion permselectivity, ion concentration polarization, and ionic current rectification (ICR). Based on ICR, the analytical applications of nanopore can be realized by monitoring ionic current change when the analyte molecule recognition events occur inside nanopore. To better understand ICR based nanopore sensing, its recent advances are reviewed and categorized in two main sensing strategies including nanopore inner surface charge variation and nanopore inner molecular conformation change. Moreover, the nanopore regeneration strategies are also reviewed. The future challenges and opportunities in ICR based nanopore sensing are further discussed. This review is expected to expedite the research and development of nanopore analytical applications.

Published in Sensors and Actuators Reports

ISSN: 2666-0539 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Mathematics: Instruments and machines
Website: https://www.journals.elsevier.com/sensors-and-actuators-reports/

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