Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin–ligand-type complexes

Abstract

Ribosomes assemble through a process involving about 200 biogenesis factors and series of remodeling steps. Here the authors present the structures of the Rea1-MIDAS domain alone and in complex with its binding partners, shedding light on the process of mechanochemical release of the assembly factors Rsa4 and Ytm1 from the pre-60S particle.