Nature Communications (Jun 2016)

Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein

  • Amar Nath Gupta,
  • Krishna Neupane,
  • Negar Rezajooei,
  • Leonardo M. Cortez,
  • Valerie L. Sim,
  • Michael T. Woodside

DOI
https://doi.org/10.1038/ncomms12058
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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Small-molecule chaperones that can prevent protein misfolding have potential applications for treating diseases such as Alzheimer’s and ALS. Here the authors use high-resolution force spectroscopy to gain insight into the mechanism of action of an iron-tetrapyrrole with anti-prion properties.