多模态磁共振成像评估急性缺血性卒中缺血半暗带的研究进展 Advance in Detection of Ischemic Penumbra in Acute Ischemic Stroke Using Multimodal Magnetic Resonance Imaging

Abstract

【摘要】 急性缺血性卒中（acute ischemic stroke，AIS）的缺血半暗带（ischemic penumbra，IP）一直是急性血管内介入治疗中影像评估关注的重点和热点问题。由于多模态MRI可以提供丰富的病理生理学参数，在IP临床评估中具有良好前景。本文对各类MRI成像策略对于IP评估的特点与局限进行介绍，重点介绍了新型技术酰胺质子转移成像（amide proton transfer，APT）。APT通过对脑缺血区域细胞内pH值的精确判断，能够准确评估IP。虽然目前APT临床应用尚少，但随着其成像技术的不断改进，有望成为辅助决策AIS患者治疗的重要影像学检查手段。 【Abstract】 Ischemic penumbra (IP) in acute ischemic stroke (AIS) has always been the focus of imaging evaluation in acute endovascular treatment. Because multimodal MRI can provide many pathophysiological parameters, using multimodal MRI to evaluate IP is promising. This article introduced the characteristics and limitation of different MRI sequence for assessing IP, with emphasis on the new technology amide proton transfer (APT) imaging, which can properly evaluate IP through accurate determination of intracellular pH value in cerebral ischemia region. Although APT is rarely used in clinical examination at present, it is believed that APT will become an important imaging technique for the diagnosis and treatment of AIS patients in the future, with the improvement of imaging technology.

Keywords

• 缺血性卒中
• 磁共振成像
• 酰胺质子转移成像
• 缺血半暗带
• ischemic stroke
• magnetic resonance imaging
• amide proton transfer imaging;ischemic penumbra