A variant of acute promyelocytic leukemia with t(4;17)(q12;q21) showed two different clinical symptoms

Takahisa Nakanishi; Aya Nakaya; Yusuke Nishio; Shinya Fujita; Atsushi Satake; Yoshiko Azuma; Yukie Tsubokura; Ryo Saito; Akiko Konishi; Masaaki Hotta; Hideaki Yoshimura; Yoshihiko Kadosaka; Kazuyoshi Ishii; Tomoki Ito; Koji Tsuta; Shosaku Nomura

doi:10.4081/hr.2019.7971

Hematology Reports (Sep 2019)

A variant of acute promyelocytic leukemia with t(4;17)(q12;q21) showed two different clinical symptoms

Takahisa Nakanishi,
Aya Nakaya,
Yusuke Nishio,
Shinya Fujita,
Atsushi Satake,
Yoshiko Azuma,
Yukie Tsubokura,
Ryo Saito,
Akiko Konishi,
Masaaki Hotta,
Hideaki Yoshimura,
Yoshihiko Kadosaka,
Kazuyoshi Ishii,
Tomoki Ito,
Koji Tsuta,
Shosaku Nomura

Affiliations

Takahisa Nakanishi: First Department of Internal Medicine, Kansai Medical University, Osaka
Aya Nakaya: First Department of Internal Medicine, Kansai Medical University, Osaka
Yusuke Nishio: Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka
Shinya Fujita: First Department of Internal Medicine, Kansai Medical University, Osaka
Atsushi Satake: First Department of Internal Medicine, Kansai Medical University, Osaka
Yoshiko Azuma: First Department of Internal Medicine, Kansai Medical University, Osaka
Yukie Tsubokura: First Department of Internal Medicine, Kansai Medical University, Osaka
Ryo Saito: First Department of Internal Medicine, Kansai Medical University, Osaka
Akiko Konishi: First Department of Internal Medicine, Kansai Medical University, Osaka
Masaaki Hotta: First Department of Internal Medicine, Kansai Medical University, Osaka
Hideaki Yoshimura: First Department of Internal Medicine, Kansai Medical University, Osaka
Yoshihiko Kadosaka: Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka
Kazuyoshi Ishii: First Department of Internal Medicine, Kansai Medical University, Osaka
Tomoki Ito: First Department of Internal Medicine, Kansai Medical University, Osaka
Koji Tsuta: Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka
Shosaku Nomura: First Department of Internal Medicine, Kansai Medical University, Osaka

DOI: https://doi.org/10.4081/hr.2019.7971
Journal volume & issue: Vol. 11, no. 3

Abstract

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A 63-year-old man was diagnosed with a rare variant of acute promyelocytic leukemia (APL) with t(4;17)(q12; q21) that showed atypical morphological features and two different clinical symptoms. He was started on standard induction chemotherapy for acute myeloid leukemia, which decreased myeloblast numbers; however, APL-like blasts remained. He then received a salvage therapy that added all-trans retinoic acid (ATRA). After ATRA commenced, APL-like blasts disappeared and cytogenetic analysis became normal. However, myeloblasts subsequently increased, and he became resistant. In summary, this patient exhibited two different clinical courses of acute myeloid leukemia and APL.

Published in Hematology Reports

ISSN: 2038-8330 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://www.mdpi.com/journal/hematolrep

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