Electrochemical corrosion behaviour of AZ91E magnesium alloy by means of various nanocoatings in aqueous peritoneal solution: in vitro and in vivo studies

Abstract

The corrosion resistance for magnesium alloy is enhanced by means of drug/nanopolymer coating that was developed to be protective and to prevent inflammation and pain; these are the most desired characteristics of laparoscopic sleeve gastrectomy staples implants. The coatings are prepared from the biocompatible gelatin nanoparticle (GEL-NPs), chitosan nanoparticle and cellulose acetate phthalate nanoparticle (CAP-NPs) with the non-steroid anti-inflammatory drug (NSAID), diclofenac. The outcomes presented that the GEL-NPs coating with glutaraldehyde as a crosslinker is the utmost corrosion resistant one with lowest hydrogen evolution rate and efficacy of 97.9%; this is due to this coating shield the effect of the surrounding environment. However, CAP-NPs stay for a longer time than any other tested coating here. The corrosion resistance and hydrogen evolution were examined with potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. Cyclic voltammetry (CV) was used to characterize the electrochemical behavior of the drug release in a peritoneal fluid electrolyte.

Keywords

• Diclofenac
• Laparoscopic sleeve gastrectomy
• Drug release
• Inhibitors