Clinical and Translational Radiation Oncology (Nov 2024)
Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)
- K. Zwart,
- M.N.G.J.A. Braat,
- F.H. van der Baan,
- A.M. May,
- J.M.L. Roodhart,
- D. Al-Toma,
- J.M.M.B. Otten,
- M. Los,
- T. Oostergo,
- R.J.A. Fijneman,
- J.M. van Dodewaard-de Jong,
- C.J.A Punt,
- G. Meijer,
- J.J.W. Lagendijk,
- M. Koopman,
- M. Intven,
- G.M. Bol
Affiliations
- K. Zwart
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- M.N.G.J.A. Braat
- Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- F.H. van der Baan
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- A.M. May
- Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- J.M.L. Roodhart
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- D. Al-Toma
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- J.M.M.B. Otten
- Department of Oncology, Meander Medical Centre, Amersfoort, the Netherlands
- M. Los
- Department of Oncology, St. Antonius, Nieuwegein, the Netherlands
- T. Oostergo
- Department of Oncology, Diakonessenhuis, Utrecht, the Netherlands
- R.J.A. Fijneman
- Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands
- J.M. van Dodewaard-de Jong
- Department of Oncology, Meander Medical Centre, Amersfoort, the Netherlands
- C.J.A Punt
- Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- G. Meijer
- Department of Radiotherapy, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- J.J.W. Lagendijk
- Department of Radiotherapy, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- M. Koopman
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- M. Intven
- Department of Radiotherapy, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
- G.M. Bol
- Department of Medical Oncology, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiotherapy, Imaging & Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Corresponding author.
- Journal volume & issue
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Vol. 49
p. 100874
Abstract
Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.
