Journal of Inflammation Research (Oct 2023)

The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis

  • Jiao P,
  • Li Z,
  • Li B,
  • Jiao X

Journal volume & issue
Vol. Volume 16
pp. 4471 – 4479

Abstract

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Pengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic of China; 3Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, People’s Republic of China; 4Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xingyuan Jiao, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510000, People’s Republic of China, Tel +86-13178813750, Email [email protected]: Peri-implantitis is an important cause of oral implant failure. In the past, TLR4 and TLR2 in the Toll-like family were generally considered as the key immune recognition receptors regulating peri-implantitis. However, under the guidance of this theory, there are still some unexplainable peri-implantitis symptoms. With the discovery of novel intracellular LPS receptor Caspase-11, a new understanding of inflammatory signaling and immune regulation in the development of peri-implantitis has been gained. However, the regulatory role of Caspase-11 in peri-implantitis and its crosstalk with the TLR4 pathway remain unclear. The therapeutic effect of drugs targeting Caspase-11 on peri-implantitis is still in its early stages. In view of this situation, this paper reviews the possible role of Caspase-11 in peri-implant inflammation, elaborated the entry process of LPS and the activation mechanism of Caspase-11, and analyzes the differences in Caspase-11 between commonly studied animals, mice and humans. The current research hotspots and challenges are also analyzed to provide new insights and ideas for researchers.Keywords: caspase-11, pyroptosis, inflammation, peri-implantitis

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