CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead

Qingyang Zhang; Jieming Ping; Zirui Huang; Xiaoli Zhang; Jingyi Zhou; Gangyang Wang; Shaoyang Liu; Jianjun Ma

doi:10.1155/2020/1924379

Journal of Immunology Research (Jan 2020)

CAR-T Cell Therapy in Cancer: Tribulations and Road Ahead

Qingyang Zhang,
Jieming Ping,
Zirui Huang,
Xiaoli Zhang,
Jingyi Zhou,
Gangyang Wang,
Shaoyang Liu,
Jianjun Ma

Affiliations

Qingyang Zhang: Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan 453003, China
Jieming Ping: Division of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zirui Huang: Human Anatomy Laboratory, School of International Education, Xinxiang Medical University, Henan 453003, China
Xiaoli Zhang: Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan 453003, China
Jingyi Zhou: Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan 453003, China
Gangyang Wang: Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Shaoyang Liu: Department of Orthopedics, Shanghai Putuo District Central Hospital, Shanghai 200062, China
Jianjun Ma: Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan 453003, China

DOI: https://doi.org/10.1155/2020/1924379
Journal volume & issue: Vol. 2020

Abstract

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Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. Like other technologies, CAR-T cell therapy has undergone a long development process, and persistent explorations of the actions of the intracellular signaling domain and make several improvements have led to the superior efficacy when anti-CD19 CAR-T cell treatments in B cell cancers. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. This review mainly describes the toxicity of CAR-T cell therapy and the challenges of CAR-T cells in the treatment of solid tumors, and looks forward to future development and opportunities for immunotherapy and reviews major breakthroughs in CAR-T cell therapy.

Published in Journal of Immunology Research

ISSN: 2314-8861 (Print); 2314-7156 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://onlinelibrary.wiley.com/journal/1607

About the journal