Promising Future of PRP Treatment for Ovarian Rejuvenation: An In-House Experience of an IVF Institute

Abstract

Objectives: Over the past few years platelet-rich plasma (PRP) has been shown to have beneficial effects on various organs and sites in the human body. Its effect on restoration of tissue engineering has gained tremendous popularity. Its effect in the field of reproductive medicine only got implemented in last decade. Methods: In this retrospective observational study, we observed 84 cases of ovarian rejuvenation at a fertility clinic from the year 2016 to 2019, out of which 45 were done for the indication of primary ovarian insufficiency for females that fall in the category 3 and 4 of Poseidon criterion. We did an autologous PRP ovarian treatment for each participant. The primary outcome was achieving a biological pregnancy after the procedure. Results: Out of 45 patients in the present study, 27 had achieved biological pregnancy, of which Eight were natural pregnancies, and the remaining 19 had received IVF or IUI as a fertility treatment. Out of these 27 biological pregnancies, 20 patients had a live birth, one had an ectopic pregnancy, and six had miscarriages. Conclusions: The process of autologous intraovarian treatment with PRP definitely helped patients with diminished ovarian reserve to conceive their own genetic offsprings, whose otherwise best option would have been to go through a donor egg program. Hence, PRP definitely deserves a place in the field of reproductive medicine to combat the condition of premature ovarian failure.

Keywords

• Platelet-Rich Plasma (PRP)
• Ovarian Rejuvenation
• Intraovarian PRP Infusion
• Diminished Ovarian Reserve (DOR)
• In Vitro Fertilization (IVF)
• Regenerative Medicine