Nature Communications (Jun 2018)
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge
- Navid Madani,
- Amy M. Princiotto,
- Linh Mach,
- Shilei Ding,
- Jérémie Prevost,
- Jonathan Richard,
- Bhavna Hora,
- Laura Sutherland,
- Connie A. Zhao,
- Brandon P. Conn,
- Todd Bradley,
- M. Anthony Moody,
- Bruno Melillo,
- Andrés Finzi,
- Barton F. Haynes,
- Amos B. Smith III,
- Sampa Santra,
- Joseph Sodroski
Affiliations
- Navid Madani
- Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
- Amy M. Princiotto
- Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
- Linh Mach
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Shilei Ding
- Centre de Recherche du CHUM
- Jérémie Prevost
- Centre de Recherche du CHUM
- Jonathan Richard
- Centre de Recherche du CHUM
- Bhavna Hora
- Department of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical Center
- Laura Sutherland
- Department of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical Center
- Connie A. Zhao
- Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
- Brandon P. Conn
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Todd Bradley
- Department of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical Center
- M. Anthony Moody
- Department of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical Center
- Bruno Melillo
- Department of Chemistry, University of Pennsylvania
- Andrés Finzi
- Centre de Recherche du CHUM
- Barton F. Haynes
- Department of Medicine, Department of Immunology, Duke Human Vaccine Institute, Duke University Medical Center
- Amos B. Smith III
- Department of Chemistry, University of Pennsylvania
- Sampa Santra
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Joseph Sodroski
- Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-018-04758-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human primate model of infection.
