Macrocystic and non-necrotic salivary duct carcinoma of the submandibular gland: A case report

Kenji Yorita, MD, PhD; Katsushi Miyazaki, MD, PhD; Makoto Urano, MD, PhD; Toshitaka Nagao, MD, PhD; Masato Nakaguro, MD, PhD; Kazuhiko Tahara, MD; Takashi Takeda, MD; Kimiko Nakatani, MD, PhD

Radiology Case Reports (Aug 2024)

Macrocystic and non-necrotic salivary duct carcinoma of the submandibular gland: A case report

Kenji Yorita, MD, PhD,
Katsushi Miyazaki, MD, PhD,
Makoto Urano, MD, PhD,
Toshitaka Nagao, MD, PhD,
Masato Nakaguro, MD, PhD,
Kazuhiko Tahara, MD,
Takashi Takeda, MD,
Kimiko Nakatani, MD, PhD

Affiliations

Kenji Yorita, MD, PhD: Department of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, 1-4-63-11 Hadaminamimachi, Kochi-shi, Kochi 780-8562, Japan; Corresponding author.
Katsushi Miyazaki, MD, PhD: Department of Otorhinolaryngology, Japanese Red Cross Kochi Hospital, 1-4-63-11 Hadaminamimachi, Kochi-shi, Kochi 780-8562, Japan
Makoto Urano, MD, PhD: Department of Diagnostic Pathology, Fujita Health University Bantane Hospital, Nagoya-shi, 3-6-10 Otobashi, Nakagawa-ku, Nagoya-shi, Aichi 454-8509, Japan
Toshitaka Nagao, MD, PhD: Department of Anatomic Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Masato Nakaguro, MD, PhD: Department of Pathology and Laboratory Medicine, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan
Kazuhiko Tahara, MD: Department of Otorhinolaryngology, Japanese Red Cross Kochi Hospital, 1-4-63-11 Hadaminamimachi, Kochi-shi, Kochi 780-8562, Japan
Takashi Takeda, MD: Department of Otorhinolaryngology, Japanese Red Cross Kochi Hospital, 1-4-63-11 Hadaminamimachi, Kochi-shi, Kochi 780-8562, Japan
Kimiko Nakatani, MD, PhD: Department of Radiology, Japanese Red Cross Kochi Hospital, 1-4-63-11 Hadaminamimachi, Kochi-shi, Kochi 780-8562, Japan

Journal volume & issue: Vol. 19, no. 8
pp. 3049 – 3055

Abstract

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Salivary duct carcinoma (SDC) is a major malignant salivary gland tumor that usually forms a solid tumor. Non-necrotic macrocystic SDCs have rarely been reported among salivary gland tumors. A 78-year-old Japanese man with a submandibular gland tumor was evaluated radiologically, pathologically, and immunohistochemically. A multilocular lesion with a maximum size of 6 cm was radiologically observed in the left submandibular region. It had been noticed 20 years earlier. Malignant cytological result was obtained, and surgical resection was performed. Pathological examination revealed a non-necrotic, macrocystic submandibular gland tumor lined with glandular, cribriform, or papillary forms of atypical cuboidal cells. Frankly invasive components were observed in intercystic areas. Intraductal, mucoepidermoid, and secretory carcinomas were identified as pathological differential diagnoses because of their macrocystic morphology. We diagnosed SDC because there was no intraductal growth based on the lack of myoepithelial markers, diffuse immunoreactivity to gross cystic disease fluid protein15, androgen receptor, and mammaglobin and immunonegativity to S100 and p63. Postoperative positron emission tomography revealed the absence of lymph node and distant metastases. The patient was disease-free 9 months after surgery. Salivary duct carcinoma can be included in the differential diagnoses of cystic salivary gland tumors.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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