Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

Vlad-Stefan Raducanu; Muhammad Tehseen; Amani Al-Amodi; Luay I. Joudeh; Alfredo De Biasio; Samir M. Hamdan

doi:10.1038/s41467-022-34751-2

Nature Communications (Nov 2022)

Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

Vlad-Stefan Raducanu,
Muhammad Tehseen,
Amani Al-Amodi,
Luay I. Joudeh,
Alfredo De Biasio,
Samir M. Hamdan

Affiliations

Vlad-Stefan Raducanu: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology
Muhammad Tehseen: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology
Amani Al-Amodi: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology
Luay I. Joudeh: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology
Alfredo De Biasio: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology
Samir M. Hamdan: Bioscience Program, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-34751-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Here, the authors investigate the maturation of Okazaki fragments with human proteins and reveal that initiator RNA removal occurs non-processively and slowly suggesting that additional pathways might exist to accelerate RNA removal in cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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