Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

Juntao Chen; Cuidi Xu; Kun Yang; Rifeng Gao; Yirui Cao; Lifei Liang; Siyue Chen; Shihao Xu; Ruiming Rong; Jina Wang; Tongyu Zhu

doi:10.1038/s41467-023-36747-y

Nature Communications (Mar 2023)

Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

Juntao Chen,
Cuidi Xu,
Kun Yang,
Rifeng Gao,
Yirui Cao,
Lifei Liang,
Siyue Chen,
Shihao Xu,
Ruiming Rong,
Jina Wang,
Tongyu Zhu

Affiliations

Juntao Chen: Department of Urology, Zhongshan Hospital, Fudan University
Cuidi Xu: Department of Urology, Zhongshan Hospital, Fudan University
Kun Yang: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases
Rifeng Gao: The Fifth People’s Hospital of Shanghai, Fudan University
Yirui Cao: Department of Urology, Zhongshan Hospital, Fudan University
Lifei Liang: Department of Urology, Zhongshan Hospital, Fudan University
Siyue Chen: Department of Urology, Zhongshan Hospital, Fudan University
Shihao Xu: Department of Urology, Zhongshan Hospital, Fudan University
Ruiming Rong: Department of Urology, Zhongshan Hospital, Fudan University
Jina Wang: Department of Urology, Zhongshan Hospital, Fudan University
Tongyu Zhu: Department of Urology, Zhongshan Hospital, Fudan University

DOI: https://doi.org/10.1038/s41467-023-36747-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood. Here, the authors show the role and the mechanism of the m6A demethylase, ALKBH5 on IRI induced AKI.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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