Alcohol-Induced Liver Injury: Morphological and Biochemical Features (Experimental Study)

Abstract

Study concerning the influence of additional damaging factors and chronic alcoholisation on the phospholipid composition of liver homogenate has been carried out on 42 white laboratory rats using biochemical, pathomorphological and pathophysiological methods. Chronic hepatosis with three degrees of prevalence (microvesicular, macrovesicular and globular fatty degeneration) and activity associated with corresponding changes in the permeability of the hepatocyte membranes and the dynamics of membrane protein and lipid peroxidation has been achieved in experiment and described in detail.

Keywords

• liver
• hepatosis
• fatty degeneration
• membranes of hepatocytes
• lipid peroxidation