JACS Au (Sep 2024)
Rational Design of Dual-Domain Binding Inhibitors for N‑Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms
- Ismael Compañón,
- Collin J. Ballard,
- Erandi Lira-Navarrete,
- Tanausú Santos,
- Serena Monaco,
- Juan C. Muñoz-García,
- Ignacio Delso,
- Jesus Angulo,
- Thomas A. Gerken,
- Katrine T. Schjoldager,
- Henrik Clausen,
- Tomás Tejero,
- Pedro Merino,
- Francisco Corzana,
- Ramon Hurtado-Guerrero,
- Mattia Ghirardello
Affiliations
- Ismael Compañón
- Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño, Spain
- Collin J. Ballard
- Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States
- Erandi Lira-Navarrete
- Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark
- Tanausú Santos
- Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño, Spain
- Serena Monaco
- School of Pharmacy, University of East Anglia, Norwich, U.K.
- Juan C. Muñoz-García
- School of Pharmacy, University of East Anglia, Norwich, U.K.
- Ignacio Delso
- School of Pharmacy, University of East Anglia, Norwich, U.K.
- Jesus Angulo
- School of Pharmacy, University of East Anglia, Norwich, U.K.
- Thomas A. Gerken
- Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States
- Katrine T. Schjoldager
- Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark
- Henrik Clausen
- Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark
- Tomás Tejero
- Department of Organic Chemistry, Faculty of Sciences, University of Zaragoza, Zaragoza, Spain
- Pedro Merino
- Department of Organic Chemistry, Faculty of Sciences, University of Zaragoza, Zaragoza, Spain
- Francisco Corzana
- Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño, Spain
- Ramon Hurtado-Guerrero
- Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark
- Mattia Ghirardello
- Department of Chemistry and Instituto de Investigación en Química de la Universidad de La Rioja, Universidad de La Rioja, Logroño, Spain
- DOI
- https://doi.org/10.1021/jacsau.4c00633
- Journal volume & issue
-
Vol. 4,
no. 9
pp. 3649 – 3656
Abstract
No abstracts available.
