The SMAC mimetic AZD5582 reverses HIV latency as a single agent in resting primary CD4+ T cells

• G. Sampey,
• D. Irlbeck,
• E. Browne,
• M. Kanke,
• E. Cule,
• S. Wills,
• S. Falcinelli,
• Z. Wang,
• J. Kircherr,
• B. Allard,
• E. Stuelke,
• K. Sholtis,
• R. Ferris,
• J. Brehm,
• D. Favre,
• J.-P. Routy,
• C. Jones,
• N. Archin,
• D. Margolis,
• R. Dunham

Affiliations

G. Sampey

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; Qura Therapeutics, Chapel Hill, NC, USA

D. Irlbeck

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; ViiV Healthcare, Research Triangle Park, USA

E. Browne

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; Qura Therapeutics, Chapel Hill, NC, USA

M. Kanke

University of North Carolina at Chapel Hill, Departments of Biology and Genetics, Chapel Hill, NC, USA

E. Cule

GlaxoSmithKline, Research and Development, Stevenage, UK

S. Wills

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; Qura Therapeutics, Chapel Hill, NC, USA

S. Falcinelli

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

Z. Wang

GlaxoSmithKline, Research and Development, Collegeville, PA, USA

J. Kircherr

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

B. Allard

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

E. Stuelke

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

K. Sholtis

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

R. Ferris

ViiV Healthcare, Research Triangle Park, USA

J. Brehm

ViiV Healthcare, Research Triangle Park, USA

D. Favre

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

J.-P. Routy

McGill University Health Centre, Chronic Viral Infection Service and Division of Hematology, Montreal, Canada

C. Jones

University of North Carolina at Chapel Hill, Departments of Biology and Genetics, Chapel Hill, NC, USA

N. Archin

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA

D. Margolis

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; Qura Therapeutics, Chapel Hill, NC, USA

R. Dunham

University of North Carolina at Chapel Hill, Dept of Medicine, UNC HIV Cure Center, Chapel Hill, NC, USA; Qura Therapeutics, Chapel Hill, NC, USA; ViiV Healthcare, Research Triangle Park, USA