SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu; Guanglei Wang; Xiaohu Huang; Hangnoh Lee; Jin-Gu Lee; Penghua Yang; Joyce van de Leemput; Weiliang Huang; Maureen A. Kane; Peixin Yang; Zhe Han

doi:10.1038/s42003-022-03986-6

Communications Biology (Sep 2022)

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu,
Guanglei Wang,
Xiaohu Huang,
Hangnoh Lee,
Jin-Gu Lee,
Penghua Yang,
Joyce van de Leemput,
Weiliang Huang,
Maureen A. Kane,
Peixin Yang,
Zhe Han

Affiliations

Jun-yi Zhu: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine
Guanglei Wang: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Xiaohu Huang: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine
Hangnoh Lee: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine
Jin-Gu Lee: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine
Penghua Yang: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Joyce van de Leemput: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine
Weiliang Huang: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy
Maureen A. Kane: Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy
Peixin Yang: Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine
Zhe Han: Center for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03986-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

SARS-CoV-2 protein expression studies in the Drosophila heart suggest a cause of COVID-19-associated cardiac pathology via interaction of virus Nsp6 with the host MGA/MAX complex disrupting glycolysis and cardiac mitochondrial function.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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