Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility

Chongyang Li; Francis P. McManus; Cédric Plutoni; Cristina Mirela Pascariu; Trent Nelson; Lara Elis Alberici Delsin; Gregory Emery; Pierre Thibault

doi:10.1038/s41467-020-14581-w

Nature Communications (Feb 2020)

Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility

Chongyang Li,
Francis P. McManus,
Cédric Plutoni,
Cristina Mirela Pascariu,
Trent Nelson,
Lara Elis Alberici Delsin,
Gregory Emery,
Pierre Thibault

Affiliations

Chongyang Li: Institute for Research in Immunology and Cancer, Université de Montréal
Francis P. McManus: Institute for Research in Immunology and Cancer, Université de Montréal
Cédric Plutoni: Institute for Research in Immunology and Cancer, Université de Montréal
Cristina Mirela Pascariu: Institute for Research in Immunology and Cancer, Université de Montréal
Trent Nelson: Institute for Research in Immunology and Cancer, Université de Montréal
Lara Elis Alberici Delsin: Institute for Research in Immunology and Cancer, Université de Montréal
Gregory Emery: Institute for Research in Immunology and Cancer, Université de Montréal
Pierre Thibault: Institute for Research in Immunology and Cancer, Université de Montréal

DOI: https://doi.org/10.1038/s41467-020-14581-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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PIAS1 is an E3 SUMO ligase involved in various cellular processes. Here, the authors use quantitative proteomics to identify potential PIAS1 substrates in human cells and elucidate the biological consequences of PIAS1-mediated SUMOylation of vimentin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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