Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism
Sijin Hang,
Hui Chen,
Wenhui Wu,
Shiyi Wang,
Yiwen Fang,
Ruilong Sheng,
Qidong Tu,
Ruihua Guo
Affiliations
Sijin Hang
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Hui Chen
Shanghai Engineering Center of Hadal Science and Technology, College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China
Wenhui Wu
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Shiyi Wang
AIEN Institute, Shanghai Ocean University, Shanghai 201306, China
Yiwen Fang
Department of Chemistry, College of Science, Shantou University, Shantou 515063, China
Ruilong Sheng
CQM-Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9000-390 Funchal, Portugal
Qidong Tu
Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China
Ruihua Guo
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse bioactivities such as thrombolysis, anti-inflammatory and anti-oxidative properties, and so on. It may be widely used for the treatment of various diseases, including cerebral infarction, stroke, ischemia/reperfusion damage, acute kidney injury, etc. Especially in cerebral infarction, compound 1 could reduce hemorrhagic transformation along with thrombolytic therapy, as the traditional therapies are accompanied with bleeding risks. In the latest studies, compound 1 selectively inhibited the growth of NSCLC cells with EGFR mutation, thus demonstrating its excellent anti-cancer activity. Herein, we summarized pharmacological activities, preparation of staplabin congeners—especially compound 1—and the mechanism of compound 1, with potential therapeutic applications.
