Мать и дитя в Кузбассе (Jul 2022)
HYPEREOSINOPHILIC SYNDROME AND SKIN LESIONS IN CHILDREN IN THE PRACTICE OF THE PEDIATRICIAN
Abstract
An eosinophil level of more than 15-20 % or 1500 cells is defined as hypereosinophilia, hypereosinophilic syndrome or «large eosinophilia». Organs and systems are affected in this situation due to the release of biologically active substances. Paediatric hypereosinophilia occurs at a rate of 54.4 per 100000 people per year. Clinical picture, final diagnosis, reaction to treatment and prognosis of this pathology remain insufficiently studied in children. It is important to identify the underlying diseases for which treatment can be directed, rather than treating eosinophilia itself. The aim of the study – Using clinical examples, to show the need for a detailed examination of children with a clinical picture of atopic dermatitis and the presence of «large eosinophilia» in the general blood test to exclude serious diseases. Materials. The study presents clinical cases of three patients observed in the clinic of the Kuzbass Children's Clinical Hospital in Novokuznetsk. Results. Infants with atopic dermatitis and hypereosinophilia require further evaluation to rule out immune status disorders. The presence of recurrent bacterial infections in these patients may be a marker of primary immunodeficiency. In a part of patients, the immune status disorder has a transient character, which aggravates the course of atopic dermatitis at the expense of skin infection, but allows to achieve remission on antimicrobial, antifungal and substitute therapy. We can not exclude the negative effect of COVID-19 in a woman during pregnancy on the formation of the immune system of the unborn child.
