Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm

Doddy Irawan Setyo Utomo; Sabar Pambudi; Enoch Y. Park

doi:10.1186/s13568-022-01353-6

AMB Express (Jan 2022)

Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm

Doddy Irawan Setyo Utomo,
Sabar Pambudi,
Enoch Y. Park

Affiliations

Doddy Irawan Setyo Utomo: Laboratory of Biotechnology, Department of Bioscience, Graduate School of Science and Technology, Shizuoka University
Sabar Pambudi: Center of Pharmaceutical and Medical Technology, National Research and Innovation Agency (BRIN), Jl. Kawasan Puspiptek, Gedung I LAPTIAB
Enoch Y. Park: Laboratory of Biotechnology, Department of Bioscience, Graduate School of Science and Technology, Shizuoka University

DOI: https://doi.org/10.1186/s13568-022-01353-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Highlights Dengue virus-like particles for serotype 1 and serotype 4 (DENV-LPs/1 and DENV-LPs/4) were produced in silkworm. Heparin-binding assay by ELISA and ITC showed that DENV-LPs/1 and DENV-LPs/4 contain Envelope Domain III. DENV-LPs/1 and DENV-LPs/4 showed affinity to sera from human dengue patients and immunized mice.

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

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Abstract

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