Antinociceptive and Anti-inflammatory Effects of Hydroalchoholic Extract of Anethum graveolens L. seed

Abstract

Background: There are many reports about anti-inflammatory effect of Anethum graveolens L.(A.g) in Iranian traditional medicine. In current decade, based on using of neutriceuticales for healing, the use of herbal drugs became very common. Objective: In this study, regarding the mentioned purposes, we have evaluated anti-inflammatory and antinociceptive effects of Hydroalchoholic Extract of A.g seeds. Methods: In this research, male mice were used and in inflammatory test they were divided to 6 groups: control, dexamethasone (15 mg/kg), seed A.g. extract (100,200, 400,500mg/kg). All of the drugs were administered intraperitonally. The inflammation was caused by xylene-induced ear oedema. In order to evaluate the antinocicetive of Anethum graveolens L. seed, we used formalin test. Mice were divided to 6 groups: control, seed A.g. extract (100,200, 400, 500 mg/kg). All of drugs were administered intraperitonally. Results: The results indicated that A.g. extract has anti-inflammatory and antinociceptive effects. Conclusion: This study suggests A.g extract as a candidate for pain relieving for further studies.

Keywords

• anthum graveolens l. seed
• inflammation
• nociception
• xylene-induced ear oedema
• formalin test