PLoS ONE (Jan 2021)

Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies.

  • Ashutosh Wadhwa,
  • Sherry Yin,
  • Brandi Freeman,
  • Rebecca B Hershow,
  • Marie Killerby,
  • Anna R Yousaf,
  • Sandra Lester,
  • Lisa Mills,
  • Sean A Buono,
  • Mary Pomeroy,
  • Daniel Owusu,
  • Victoria T Chu,
  • Jacqueline E Tate,
  • Sanjib Bhattacharyya,
  • Patricia Hall,
  • Natalie J Thornburg,
  • Hannah L Kirking

DOI
https://doi.org/10.1371/journal.pone.0255208
Journal volume & issue
Vol. 16, no. 7
p. e0255208

Abstract

Read online

Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott ArchitectTM SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results.