Nature Communications (Mar 2023)
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression
- Ce Tang,
- Haiyang Sun,
- Motohiko Kadoki,
- Wei Han,
- Xiaoqi Ye,
- Yulia Makusheva,
- Jianping Deng,
- Bingbing Feng,
- Ding Qiu,
- Ying Tan,
- Xinying Wang,
- Zehao Guo,
- Chanyan Huang,
- Sui Peng,
- Minhu Chen,
- Yoshiyuki Adachi,
- Naohito Ohno,
- Sergio Trombetta,
- Yoichiro Iwakura
Affiliations
- Ce Tang
- Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhong Shan Er Lu
- Haiyang Sun
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Motohiko Kadoki
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Wei Han
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Xiaoqi Ye
- Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhong Shan Er Lu
- Yulia Makusheva
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- Jianping Deng
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Bingbing Feng
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Ding Qiu
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Ying Tan
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Xinying Wang
- Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University
- Zehao Guo
- Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhong Shan Er Lu
- Chanyan Huang
- Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University
- Sui Peng
- Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhong Shan Er Lu
- Minhu Chen
- Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, No.58, Zhong Shan Er Lu
- Yoshiyuki Adachi
- Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji
- Naohito Ohno
- Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji
- Sergio Trombetta
- Boehringer Ingelheim USA
- Yoichiro Iwakura
- Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science
- DOI
- https://doi.org/10.1038/s41467-023-37229-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
The effect of β-glucans and their receptor Dectin-1 in tumor development remains controversial. Here the authors show that Dectin-1 signaling promotes the development of colorectal cancer (CRC) by inducing prostaglandin E2 production in myeloid-derived suppressor cells and by suppressing IL-22BP expression, suggesting dectin-1 blockade as a potential therapeutic target for CRC.
