Srpski Arhiv za Celokupno Lekarstvo (Jan 2014)

Changes in the retrobulbar hemodynamic parameters after decreasing the elevated intraocular pressure in primary open-angle glaucoma patients

  • Marjanović Ivan,
  • Martinez Antonio,
  • Marjanović Marija,
  • Milić Nataša,
  • Kontić Đorđe,
  • Hentova-Senćanić Paraskeva,
  • Marković Vujica,
  • Božić Marija

DOI
https://doi.org/10.2298/SARH1406286M
Journal volume & issue
Vol. 142, no. 5-6
pp. 286 – 290

Abstract

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Introduction. Ocular blood flow (OBF) disturbances could be involved both in the pathogenesis and in progression of glaucomatous damage. Objective. The aim of the study was to compare the retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior cilliary arteries (SPCA) after decreasing the elevated intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients by using color Doppler imaging (CDI). Methods. We examined 60 patients (21 male and 39 female) with diagnosed and treated POAG. Thirtynine patients had increased IOP (>25 mm Hg). Peak-systolic velocity (PSV), end-diastolic velocity (EDV), Pourcelot resistance index (RI), and pulsatility index (PI) were assessed in the OA, CRA, and SPCA. IOP was measured both with the Goldmann Applanation tonometer (GAT) and with the Dynamic Contour tonometer (DCT), three times respectively. Ocular pulse amplitude (OPA) was measured using DCT. Results. The retrobulbar parameters between the baseline and after IOP reduction showed no difference in measurements. After Bonferroni correction (p≤0.0056, alpha/9) statistical significance was recorded only in the following retrobulbar hemodynamic parameters; DCT (29.8±6.2 vs. 15.5±5.0), GAT (33.8±9.0 vs. 15.0±6.6) and OPA measurements (4.3±1.0 vs. 3.0±1.6), as compared to the baseline. There was no correlation between the changes in IOP measured with either DCT or GAT and changes in the hemodynamic parameters (p>0.05 for all). Pearson correlation coefficient (95% CI) showed very good correlation for IOP measurements between DCT and GAT: at baseline 0.83 (0.71 to 0.90) and at the end 0.71 (0.55 to 0.83); p0.05). Conclusion. There was a lack of correlation between the changes in IOP measured with either DCT or GAT and the changes in the hemodynamic parameters.

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