Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM

Shota Suzuki; Momoko Iida; Yoko Hiroaki; Kotaro Tanaka; Akihiro Kawamoto; Takayuki Kato; Atsunori Oshima

doi:10.1038/s42003-022-03668-3

Communications Biology (Jul 2022)

Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM

Shota Suzuki,
Momoko Iida,
Yoko Hiroaki,
Kotaro Tanaka,
Akihiro Kawamoto,
Takayuki Kato,
Atsunori Oshima

Affiliations

Shota Suzuki: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku
Momoko Iida: Division of Biological Science, School of Science, Nagoya University, Furo-cho, Chikusa-ku
Yoko Hiroaki: Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Furo-cho, Chikusa-ku
Kotaro Tanaka: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku
Akihiro Kawamoto: Institute for Protein Research, Osaka University, Suita
Takayuki Kato: Institute for Protein Research, Osaka University, Suita
Atsunori Oshima: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku

DOI: https://doi.org/10.1038/s42003-022-03668-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Cryo-electron microscopy reveals the structure and activation mechanism of MrgD, a member of the Mas-related G protein-coupled receptor family of GPCRs involved in itch and nociception.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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