Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

Samson Afewerki; Nicole Bassous; Samarah Vargas Harb; Marcus Alexandre F. Corat; Sushila Maharjan; Guillermo U. Ruiz-Esparza; Mirian M. M. de Paula; Thomas J. Webster; Carla Roberta Tim; Bartolomeu Cruz Viana; Danquan Wang; Xichi Wang; Fernanda Roberta Marciano; Anderson Oliveira Lobo

doi:10.1038/s42003-021-01758-2

Communications Biology (Feb 2021)

Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

Samson Afewerki,
Nicole Bassous,
Samarah Vargas Harb,
Marcus Alexandre F. Corat,
Sushila Maharjan,
Guillermo U. Ruiz-Esparza,
Mirian M. M. de Paula,
Thomas J. Webster,
Carla Roberta Tim,
Bartolomeu Cruz Viana,
Danquan Wang,
Xichi Wang,
Fernanda Roberta Marciano,
Anderson Oliveira Lobo

Affiliations

Samson Afewerki: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Nicole Bassous: Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University
Samarah Vargas Harb: Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University
Marcus Alexandre F. Corat: Multidisciplinary Center for Biological Research, University of Campinas (UNICAMP)
Sushila Maharjan: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Guillermo U. Ruiz-Esparza: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Mirian M. M. de Paula: Multidisciplinary Center for Biological Research, University of Campinas (UNICAMP)
Thomas J. Webster: Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University
Carla Roberta Tim: Brasil University
Bartolomeu Cruz Viana: LIMAV - Interdisciplinary Laboratory for Advanced Materials, Materials Science & Engineering Graduate Program, UFPI - Federal University of Piaui
Danquan Wang: Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University
Xichi Wang: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Fernanda Roberta Marciano: Nanomedicine Laboratory, Department of Chemical Engineering, Northeastern University
Anderson Oliveira Lobo: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s42003-021-01758-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Afewerki et al. employ integrated electrospinning, plasma treatment and direct surface modification strategy to engineer multifunctional bactericidal nanofibers for use in hernia repair. In a mouse model, they demonstrate that these nanofibers display good biological performance with low inflammatory response, good biodegradation and optimal collagen and blood vessel formation and tissue growth.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal