Effect of long-term administration of Atonik compound in female rabbits on hematological and pathological changes in important functional body organ

Abstract

Objectives This study includes the investigation of stimulant plant growth compound Atonik’s harmful effect in some important function of body organs of rabbits. Methods Twelve female rabbits weighting 1.4–1.6 kg were obtained from animal house in the college of Veterinary Medicine and they were housed for 2 weeks before the beginning of study and all laboratory condition were taken into consideration. Animals were randomly divided into two main groups: Control group without treatment at all periods of study, Atonik group: each rabbit was orally received 0.1 mg/kg/three time weekly (TIDW) and study was persistent for eight weeks. Results Our result reveals the disturbance of hematological parameters specially WBCS, RBCS, HB and lymphocyte. Moreover, histopathological section showing dilation of the central vein filled with fluid and granuloma beside it with vaculation of hypatocyte. The kidney reveals coagulative necrosis of renal tubules with the distraction of glomerular tuft. Uterus of rabbits treated with 0.1 mg/kg bw atonik for 8 weeks showing necrosis of unrein glands. Ovary showed an increase in the numbers of atretic follicles. Our result concluded that atonik has a very harmful effect for reproduction, liver and kidney. Conclusion Use of atonik plant growth hormones reveal very harmful effect in reproductive and functional organ of rabbits, In addition to that, limited use of atonik hastens plant growth specially fruits such as figs, which is characteristic with low maturity period that should be used with safety period at least 2 weeks.

Keywords

• Atonik, ovary, uterus, nitro phenol