Mediators of Inflammation (Jan 1993)

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

  • C. Zoja,
  • A. Benigni,
  • G. Piccinini,
  • M. Figliuzzi,
  • L. Longaretti,
  • G. Remuzzi

DOI
https://doi.org/10.1155/S0962935193000614
Journal volume & issue
Vol. 2, no. 6
pp. 429 – 433

Abstract

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The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.