Nature Communications (Jul 2017)

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

  • Yoshitaka Matsuo,
  • Ken Ikeuchi,
  • Yasushi Saeki,
  • Shintaro Iwasaki,
  • Christian Schmidt,
  • Tsuyoshi Udagawa,
  • Fumiya Sato,
  • Hikaru Tsuchiya,
  • Thomas Becker,
  • Keiji Tanaka,
  • Nicholas T. Ingolia,
  • Roland Beckmann,
  • Toshifumi Inada

DOI
https://doi.org/10.1038/s41467-017-00188-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.