Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Gabriel Amitai; Alexander Plotnikov; Shira Chapman; Shlomi Lazar; Rellie Gez; Dan Loewenthal; Khriesto A. Shurrush; Galit Cohen; Leonardo J. Solmesky; Haim Barr; Alan J. Russell

doi:10.1038/s42003-021-02061-w

Communications Biology (May 2021)

Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Gabriel Amitai,
Alexander Plotnikov,
Shira Chapman,
Shlomi Lazar,
Rellie Gez,
Dan Loewenthal,
Khriesto A. Shurrush,
Galit Cohen,
Leonardo J. Solmesky,
Haim Barr,
Alan J. Russell

Affiliations

Gabriel Amitai: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Alexander Plotnikov: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Shira Chapman: Department of Pharmacology, Israel Institute for Biological Research (IIBR)
Shlomi Lazar: Department of Pharmacology, Israel Institute for Biological Research (IIBR)
Rellie Gez: Department of Pharmacology, Israel Institute for Biological Research (IIBR)
Dan Loewenthal: Department of Analytical Chemistry, IIBR
Khriesto A. Shurrush: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Galit Cohen: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Leonardo J. Solmesky: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Haim Barr: The Wohl Drug Discovery Institute, Grand Israel National Center for Personalized Medicine (G-INCPM), The Weizmann Institute of Science
Alan J. Russell: Department of Chemical Engineering, Carnegie Mellon University

DOI: https://doi.org/10.1038/s42003-021-02061-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified nerve agents and also reactivated nerve agent-inhibited butyrylcholinesterase.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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