COMORBIDITY AND GOUT: ASSOCIATION BETWEEN HYPERURICEMIA AND BLOOD PARAMETERS AS A PREDICTOR OF GOUT

Abstract

Purpose: The aim of this study was to analyze the predictive potential of selected biochemical and hematological parameters in patients with gout from Bosnia and Herzegovina, and to determine the most common comorbidities related to gout. Methods: Forty patients with gout (17 males and 23 females) from the hospital in the municipality of Novi Grad, Sarajevo were included in the present study. We analyzed biochemical parameters (uric acid, urea, creatinine, and CRP), ESR, and WBC as a hematological parameter. The Shapiro-Wilk test and the Spearman correlation coefficient were used for the normality and correlation analysis, respectively. Results: Most gout patients were 50-70 years old and gout was more prevalent in female patients. Thirteen different comorbidities are related to gout. After the onset of the main disease, 82.35% of male patients were diagnosed with cardiovascular disease, while hypertension was diagnosed in 76.47% of male patients. High mean values of ESR, as well as CRP, uric acid, urea, and creatinine concentrations were found for all gout patients. A strong positive correlation was found after comparing urea and ESR (ρ=0.314); urea and creatinine (ρ=0.526); CRP and ESR (ρ=0.375). Conclusion: We can conclude that the analyzed biochemical parameters, CRP, urea, creatinine, and uric acid, as well as ESR, are good predictors of gout. High values of uric acid, creatinine, and urea are the most important gout predictors and significant markers for the development of comorbidities.

Keywords

• gout
• comorbidities
• esr
• wbc
• crp
• urea
• creatinine
• uric acid