Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis
Abstract
Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis.
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