CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Xingxin Wu; Xudong Wu; Yuxiang Ma; Fenli Shao; Yang Tan; Tao Tan; Liyun Gu; Yang Zhou; Beicheng Sun; Yang Sun; Xuefeng Wu; Qiang Xu

doi:10.1038/ncomms13498

Nature Communications (Nov 2016)

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Xingxin Wu,
Xudong Wu,
Yuxiang Ma,
Fenli Shao,
Yang Tan,
Tao Tan,
Liyun Gu,
Yang Zhou,
Beicheng Sun,
Yang Sun,
Xuefeng Wu,
Qiang Xu

Affiliations

Xingxin Wu: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Xudong Wu: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Yuxiang Ma: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Fenli Shao: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Yang Tan: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Tao Tan: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Liyun Gu: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Yang Zhou: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Beicheng Sun: Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University
Yang Sun: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Xuefeng Wu: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University
Qiang Xu: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, Nanjing University

DOI: https://doi.org/10.1038/ncomms13498
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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