Nanotomography of lesional skin using electron microscopy reveals cytosolic release of nuclear DNA in psoriasis

• Eric Lindberg, PhD,
• Yvonne Baumer, PhD,
• Erin S. Stempinski, MS,
• Justin A. Rodante, PA,
• Tiffany M. Powell-Wiley, MD, MPH,
• Amit K. Dey, MD,
• Saeko Nakajima, MD, PhD,
• Martin P. Playford, PhD,
• Christopher K.E. Bleck, PhD,
• Nehal N. Mehta, MD, MSCE, FAHA

Affiliations

Eric Lindberg, PhD

Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Yvonne Baumer, PhD

Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Erin S. Stempinski, MS

Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Justin A. Rodante, PA

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Tiffany M. Powell-Wiley, MD, MPH

Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Amit K. Dey, MD

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Saeko Nakajima, MD, PhD

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Martin P. Playford, PhD

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Christopher K.E. Bleck, PhD

Electron Microscopy Core Facility, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Nehal N. Mehta, MD, MSCE, FAHA

Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland; Correspondence to: Nehal N. Mehta, MD, MSCE, FAHA, Chief, Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, 10 Center DriveBethesda, MD 20814.