Application of nanomaterials with sulfur vacancy for enhanced cancer theranostics
Chenyu Wang,
Yingqi Wang,
Wei Tian,
Song Li,
Jixian Wan,
Yidan Wang,
Liya Tian,
Xue Wang,
Changzhong Li,
Jipeng Wan,
Xiao Sun
Affiliations
Chenyu Wang
Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Yingqi Wang
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Wei Tian
Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Song Li
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Jixian Wan
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Yidan Wang
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Liya Tian
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Xue Wang
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Changzhong Li
Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
Jipeng Wan
Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Corresponding authors.
Xiao Sun
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China; Corresponding authors.
Nanomaterials with excellent optical, electric, magnetic, and other physicochemical properties, are generally used in photodynamic therapy, chemodynamic therapy, and photothermal therapy of cancer. To enhance nanomaterials’ superior physicochemical properties and improve cancer theranostic efficiency, various strategies have been proposed. Among them, the introduction of sulfur vacancy defects is a promising strategy for enhanced cancer theranostics. In this review, the formation and action mechanism of sulfur vacancy nanomaterials, as well as their application in cancer theranostics are first summarized. Then, the principle and application of various sulfur vacancy based-nanomaterials such as molybdenum, bismuth, zinc, copper, iron, ruthenium, silver, cobalt, cadmium, and polythionine in enhancing cancer therapy are highlighted. Finally, the future development prospect and current challenges of sulfur vacancy nanomaterials are also discussed. This review will help researchers quickly understand the information related to various sulfur vacancy-based nanomaterials in cancer therapy, promoting the further development of anti-cancer nanomedicine.
