Nature Communications (Jan 2019)

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

  • Xuran Wang,
  • Jihwan Park,
  • Katalin Susztak,
  • Nancy R. Zhang,
  • Mingyao Li

DOI
https://doi.org/10.1038/s41467-018-08023-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.