P105 NEX-T CD19 chimeric antigen receptor (CAR) T-cell therapy CC-97540 (BMS-986353): Preclinical and translational evidence of deep B-cell depletion suitable for study in severe refractory autoimmune diseases

• Georg Schett,
• Fan Wu,
• Nikolay Delev,
• Ruth Salmon,
• Jerill Thorpe,
• Amitkumar Mehta,
• Tatyana Feldman,
• Jeremy Abramson,
• Boyu Hu,
• Fabien Müller,
• Ashley Koegel,
• Divya Varun,
• Alison Maier,
• David Kugler,
• Matthew Westoby

Affiliations

Georg Schett

Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany

Fan Wu

Department of Endocrinology, Tianjin Union Medical Center Tianjin People`s Hospital, Hongqiao, Tianjin, China

Nikolay Delev

Clinical R&D, Bristol Myers Squibb, Princeton, New Jersey, USA

Ruth Salmon

Bristol Myers Squibb, Seattle, WA, USA

Jerill Thorpe

6Translational Research, Bristol Myers Squibb, Princeton, NJ, USA

Amitkumar Mehta

4Birmingham Comprehensive Cancer Center, Birmingham, AL, USA

Tatyana Feldman

2John Theurer Cancer Center, Hackensack Meridian Cancer Center, Hackensack, NJ, USA

Jeremy Abramson

3Hematology/Oncology, Massachusetts General Cancer Center, Boston, MA, USA

Boyu Hu

4Dept. of Internal Medicine, University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA

Fabien Müller

1Dept. of Medicine, Friedrich Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany

Ashley Koegel

5Early Clinical Development Hematology/Cell Therapy, Bristol Myers Squibb, Princeton, NJ, USA

Divya Varun

9Drug Produce Process Development, Bristol Myers Squibb, Princeton, NJ, USA

Alison Maier

7Preclinical Sciences and Bioengineering, Cancer Immunology and Cell Therapy Thematic Research Center, Bristol Myers Squibb, Princeton, NJ, USA

David Kugler

7Preclinical Sciences and Bioengineering, Cancer Immunology and Cell Therapy Thematic Research Center, Bristol Myers Squibb, Princeton, NJ, USA

Matthew Westoby

7Preclinical Sciences and Bioengineering, Cancer Immunology and Cell Therapy Thematic Research Center, Bristol Myers Squibb, Princeton, NJ, USA