Surgical & Cosmetic Dermatology (Aug 2024)

Recombinant enzymatic products in Dermatology

  • Andreaa Nicoleta Boca,
  • Ingrid López Gehrke,
  • Carlos Lloreda,
  • Sevinj Rustamzada,
  • Jorge López Berroa

DOI
https://doi.org/10.5935/scd1984-8773.2024160306
Journal volume & issue
Vol. 16

Abstract

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Esthetic dermatology is a growing field, and different noninvasive therapies are gaining attention. The objective of this narrative review was to update current evidence-based knowledge about recombinant enzymes. The PubMed, SciELO, Cochrane Central, and Imbiomed databases were searched for meta-analyses, systematic reviews, randomized controlled clinical trials, observational registries, and preclinical data published in English, Spanish, and Portuguese. Effectivity, safety, and tolerability of recombinant hyaluronidases, lyases, collagenases, and lipases, including their combinations, were evaluated and confirmed in diverse indications. Further research could increase current knowledge on this constantly developing and promising therapeutic area.

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