HLA DRB1 alleles, IFN-γ and TGF-β Gene Variants in childhood ALL patients

Abstract

Graft-versus-host disease (GvHD) is a complex clinical syndrome with organ dysfunction as a consequence of a severe immunological reaction mediated by mainly T cells after hematopoietic stem cell transplantation. Our aim is to evaluate the association of HLA-DRB1 alleles, IFN-γ and TGF-β gene variations, with childhood ALL (c-ALL) patients and with GvHD after transplantation.

Keywords

• acute lymphoblastic leukemia
• agvhd
• cytokine
• genetic polymorphism
• hla