Kinetic resolution of cyclic benzylic azides enabled by site- and enantioselective C(sp3)–H oxidation

Abstract

Catalytic kinetic resolution of racemates is among the best ways to prepare enantiopure compounds, but this process is difficult with organic azides given the small size of the azido group. Here, the authors show kinetic resolution of cyclic benzylic azides through site- and enantioselective C(sp3)–H oxidation.