Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

Monica J. S. Nadler; Weipang Chang; Ekim Ozkaynak; Yuda Huo; Yi Nong; Morgane Boillot; Mark Johnson; Antonio Moreno; Matthew P. Anderson

doi:10.1038/s42003-023-04683-8

Communications Biology (Mar 2023)

Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation

Monica J. S. Nadler,
Weipang Chang,
Ekim Ozkaynak,
Yuda Huo,
Yi Nong,
Morgane Boillot,
Mark Johnson,
Antonio Moreno,
Matthew P. Anderson

Affiliations

Monica J. S. Nadler: Department of Neurology, Beth Israel Deaconess Medical Center
Weipang Chang: Department of Neurology, Beth Israel Deaconess Medical Center
Ekim Ozkaynak: Department of Neurology, Beth Israel Deaconess Medical Center
Yuda Huo: Department of Neurology, Beth Israel Deaconess Medical Center
Yi Nong: Department of Neurology, Beth Israel Deaconess Medical Center
Morgane Boillot: Department of Neurology, Beth Israel Deaconess Medical Center
Mark Johnson: Department of Neurology, Beth Israel Deaconess Medical Center
Antonio Moreno: Department of Neurology, Beth Israel Deaconess Medical Center
Matthew P. Anderson: Department of Neurology, Beth Israel Deaconess Medical Center

DOI: https://doi.org/10.1038/s42003-023-04683-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 17

Abstract

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Human-specific SINE-VNTR-Alu (SVA) retrotransposons in neurodevelopmental genes CDK5RAP2 and SCN8A repress their expression to delay neuronal maturation. SVA-lncRNA AK057321 binds these SVAs to release gene repression and drive neuronal maturation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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