Multi-Facial, Non-Peptidic α-Helix Mimetics

Abstract

α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.

Keywords

• α-helix mimetic
• protein–protein interaction
• proteomimetic
• amphipathic
• cancer
• Bcl-2
• HMD2
• Bak
• Bim
• p53