Sodium thiosulfate during cisplatin-based hyperthermic intraperitoneal chemotherapy is associated with transient hypernatraemia without clinical sequelae

Abstract

Cisplatin is commonly used during intraperitoneal chemotherapy however has well-established nephrotoxic side-effects. Sodium thiosulfate is often added to cisplatin-based hyperthermic intraperitoneal chemotherapy (HIPEC) protocols to mitigate this, however evidence regarding risk of hypernatraemia is scarce as of yet.

Keywords

• acute kidney injury
• cisplatin
• cytoreductive surgery
• hypernatraemia
• hyperthermic intraperitoneal chemotherapy
• sodium thiosulfate