Clinical case of liver transplantation in a kidney transplant recipient with hepatocellular cancer and сoronary artery disease

Abstract

Objective: organ transplantation is a highly effective and often the only possible definitive treatment for terminal diseases, significantly improving patient survival and quality of life. However, recipients have a higher risk of developing cardiovascular and oncological diseases, and are susceptible to decompensation of pre-existing diseases. Prevention and treatment of these conditions are becoming critical tasks in transplantology, requiring multidisciplinary collaboration. Materials and methods. This article presents a clinical case of the treatment of a patient with stage 5 chronic kidney disease, concomitant cardiologic pathologies and subsequently diagnosed hepatocellular cancer on the background of hepatitis C-related liver cirrhosis. Competent interaction and bridge therapy yielded successful consecutive kidney and liver transplantation with satisfactory outcomes. Conclusion. Our treatment experience has shown the effectiveness and necessity of a multidisciplinary approach, early diagnosis, therapy modification during transplantation and further treatment of patients with end-stage multiple organ dysfunction.

Keywords

• transplantation
• chronic kidney disease
• hepatocellular cancer
• hemodialysis
• bridge therapy