Vascular control over blood cells aggregation in patients with arterial hypertension with dyslipidemia

Abstract

There is a marked increase of prevalence of arterial hypertension (AH) in modern civilized society that usually is comorbid with dyslipidemia (DL), which leads to higher level of vascular comorbidity in economically active population, disability and mortality.Aim. To find out the specifics of antiplatelet vascular control over bloodcells in AH patients with DL.Material and methods. Totally, we studied 380 patients with AH of 1-2 grade, risk 4, with DL IIb type, of middle age. Controls were 26 healthy volunteers of the same age. We used biochemical, hematological and statistical methods of investigation.Results. In the blood of patients, there was DL IIb type revealed, withweakening of antioxidant defense and high level of lipid peroxidation. Inthe studied patients with AH and DL there was increased level oferythrocyte, platelet and neutrophil aggregation with decrease of thecontrol by vascular wall. These findings can be explained by negativeshifts of lipid metabolism, activation of peroxide oxidation of plasmalipids, receptor rebuilt of blood cells and decrease of synthesis invascular walls of nitric oxide and prostacyclin.Conclusion. For AH with DL patients it is specific to have decreasedcontrol of vascular wall over the increased aggregation of erythrocytes,platelets and neutrophils.

Keywords

• arterial hypertension
• dyslipidemia
• vessel wall
• antiaggregation
• blood cells