Subclinical hypothyreosis and pregnancy

Abstract

Subclinical hypothyreosis and pregnancy Shestakova T.P. Moscow Regional Research and Clinical Institute n. a. M. F. Vladimirskiy A special approach to diagnosis and treatment of thyroid diseases during pregnancy is caused by the physiological characteristics and importance of maintaining euthyroidism, especially in the first trimester of pregnancy. Despite numerous studies, not all the issues of diagnosis and treatment of subclinical hypothyroidism during pregnancy have been resolved. The use of trimester-specific reference range of thyrotropic hormone (TTH) is not rational, since it leads to a very high prevalence of subclinical hypothyroidism in some populations. Therefore, recently it has been shown that it is preferable to use local TTH reference ranges to diagnose this disease. The review presents the latest data on the influence of subclinical hypothyroidism on the course of pregnancy and its outcomes. It depends on the degree of increase in TTH, as well as on the presence of increased titre of antithyroid antibodies. TTH>; 2.5 mU / L affects pregnancy, therefore treatment can be useful, especially in women with increased titers of antibodies. At the period of pregnancy planning it is justified to use general population reference ranges of TTH. Treatment with TTH>; 2.5 mU / l, especially before the use of assisted reproductive technology is not justified. Key words: subclinical hypothyroidism, pregnancy, pregnancy course, pregnancy outcomes, pregnancy planning, fertility, reproductive technologies, TTH. For citation: Shestakova T.P. Subclinical hypothyreosis and pregnancy // RMJ. 2018. № 5(I). P. 56–60.