Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition

Ramkrishna Mitra; Xi Chen; Evan J. Greenawalt; Ujjwal Maulik; Wei Jiang; Zhongming Zhao; Christine M. Eischen

doi:10.1038/s41467-017-01781-0

Nature Communications (Nov 2017)

Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition

Ramkrishna Mitra,
Xi Chen,
Evan J. Greenawalt,
Ujjwal Maulik,
Wei Jiang,
Zhongming Zhao,
Christine M. Eischen

Affiliations

Ramkrishna Mitra: Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
Xi Chen: Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
Evan J. Greenawalt: Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University
Ujjwal Maulik: Department of Computer Science and Engineering, Jadavpur University
Wei Jiang: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics
Zhongming Zhao: Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston
Christine M. Eischen: Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University

DOI: https://doi.org/10.1038/s41467-017-01781-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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The role of lncRNA is unclear with respect to epithelial-to-mesenchymal transition (EMT), which is linked to ovarian cancer metastasis. Here, the authors show lncRNA DNM3OS expression contributes to ovarian cancer EMT, cell migration/invasion, and correlates with worse overall patient survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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