EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4

Abstract

This study was designed to evaluate the hepatoprotective effect of the powder Eurycoma longifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twenty five male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept as normal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV were treated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectively and CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BW p.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination of SGPT-SGOT. The study showed the activity level of SGPT from the rats was treated by Eurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groups are 150.0±5.099 U/L; 113.6±5.508 U/L; 60.5±2.887 U/L; and 129.0±6.055 U/L respectively. Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack. 100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4±11.165; 263.0±1.803; 194.5±7.448; and 451.5±16.759 U/L respectively. The Eurycoma longifolia Jack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT) than control group. The results concluded that Eurycoma longifolia Jack. powder has hepatoprotective effect.

Keywords

• Eurycoma longifolia Jack.
• hepatoprotective
• SGPT-SGOT
• CCl4